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EXPEDITED ARTICLES
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3587-3595
Discovery of (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a Farnesyltransferase Inhibitor with Potent Preclinical Antitumor Activity
John T. Hunt,
Charles Z. Ding,
Roberta Batorsky,
Mark Bednarz,
Rajeev Bhide,
Young Cho,
Saeho Chong,
Sam Chao,
Johnni Gullo-Brown,
Peng Guo,
Soong Hoon Kim,
Francis Y. F. Lee,
Katerina Leftheris,
Arthur Miller,
Toomas Mitt,
Manorama Patel,
Becky A. Penhallow,
Carol Ricca,
William C. Rose,
Robert Schmidt,
William A. Slusarchyk,
Gregory Vite, and
Veeraswamy Manne[Full Article -
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ARTICLES
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3596-3613
Synthesis and SAR of New 5-Phenyl-3-ureido-1,5-benzodiazepines as Cholecystokinin-B Receptor Antagonists
Antonella Ursini,
Anna M. Capelli,
Robin A. E. Carr,
Paolo Cassarà,
Mauro Corsi,
Ornella Curcuruto,
Giovanni Curotto,
Michele Dal Cin,
Silvia Davalli,
Daniele Donati,
Aldo Feriani,
Harry Finch,
Gabriella Finizia,
Giovanni Gaviraghi,
Marc Marien,
Giorgio Pentassuglia,
Stefano Polinelli,
Emiliangelo Ratti,
Aldo Reggiani,
Giorgio Tarzia,
Giovanna Tedesco,
Maria E. Tranquillini,
David G. Trist, and
Frank T. M. Van Amsterdam[Full Article -
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3614-3623
Replacement of Glycine with Dicarbonyl and Related Moieties in Analogues of the C-Terminal Pentapeptide of Cholecystokinin: CCK2 Agonists Displaying a Novel Binding Mode
Bruno Bellier,
Marie-Emmanuelle Million,
Sophie DaNascimento,
Hervé Meudal,
Safia Kellou,
Bernard Maigret, and
Christiane Garbay[Full Article -
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3624-3631
Crystal Structure of FMN-Dependent Nitroreductase from Escherichia coli B: A Prodrug-Activating Enzyme
Gary N. Parkinson,
Jane V. Skelly, and
Stephen Neidle[Full Article -
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3632-3640
Design, Synthesis, and SAR of Novel Carbapenem Antibiotics with High Stability to Xanthomonas maltophilia Oxyiminocephalosporinase Type II
Gholam H. Hakimelahi,
Ali A. Moosavi-Movahedi,
Shwu-Chen Tsay,
Fu-Yuan Tsai,
Jon D. Wright,
Todor Dudev,
Shahram Hakimelahi, and
Carmay Lim[Full Article -
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3641-3652
A Peptide Prodrug Approach for Improving Bisphosphonate Oral Absorption
Aviva Ezra,
Amnon Hoffman,
Eli Breuer,
Ivan S. Alferiev,
Jukka Mönkkönen,
Naama El Hanany-Rozen,
Gal Weiss,
David Stepensky,
Irith Gati,
Hagit Cohen,
Soili Törmälehto,
Gordon L. Amidon, and
Gershon Golomb[Full Article -
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3653-3664
New Substituted 1-(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)piperidin-4-yl Derivatives with  2-Adrenoceptor Antagonist Activity
Patrice Mayer,
Pascale Brunel,
Céline Chaplain,
Christel Piedecoq,
Francis Calmel,
Philippe Schambel,
Philippe Chopin,
Thierry Wurch,
Petrus J. Pauwels,
Marc Marien,
Jean-Louis Vidaluc, and
Thierry Imbert[Full Article -
PDF]
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3665-3670
Synthesis, Structure, and Antitumor Activity of a Novel Tetranuclear Titanium Complex
Francesco Caruso,
Miriam Rossi,
Joseph Tanski,
Rebeca Sartori,
Renato Sariego,
Sergio Moya,
Sylvia Diez,
Ema Navarrete,
Augusto Cingolani,
Fabio Marchetti, and
Claudio Pettinari[Full Article -
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3671-3676
Synthesis and Hypolipidemic and Antiplatelet Activities of -Asarone Isomers in Humans (in Vitro), Mice (in Vivo), and Rats (in Vivo)
Janusz Pop awski,
Bo ena  ozowicka,
Alina T. Dubis,
Barbara Lachowska,
Stanisaw Witkowski,
Danuta Siluk,
Jacek Petrusewicz,
Roman Kaliszan,
Jacek Cybulski,
Magorzata Strzakowska, and
Zdzisaw Chilmonczyk[Full Article -
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3677-3687
Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, and N-Hydroxysulfonamides Inhibit Both These Zinc Enzymes
Andrea Scozzafava and
Claudiu T. Supuran[Full Article -
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3688-3698
Synthesis of New Indeno[1,2-c]isoquinolines: Cytotoxic Non-Camptothecin Topoisomerase I Inhibitors
Mark Cushman,
Muthusamy Jayaraman,
Jeffrey A. Vroman,
Anna K. Fukunaga,
Brian M. Fox,
Glenda Kohlhagen,
Dirk Strumberg, and
Yves Pommier[Full Article -
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3699-3703
Deriving a Quantitative Chirality Measure from Molecular Similarity Indices
Romualdo Benigni,
Marina Cotta-Ramusino,
Grazia Gallo,
Fabrizio Giorgi,
Alessandro Giuliani, and
Maria Rosaria Varì[Full Article -
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3704-3713
Synthesis and Cytotoxicity of 4-Amino-5-oxopyrido[2,3-d]pyrimidine Nucleosides
Jean-Luc Girardet,
Esmir Gunic,
Cathey Esler,
Dariusz Cieslak,
Zbigniew Pietrzkowski, and
Guangyi Wang[Full Article -
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3714-3717
Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties
Peter Ertl,
Bernhard Rohde, and
Paul Selzer[Full Article -
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3718-3735
Benzo[c]quinolizin-3-ones: A Novel Class of Potent and Selective Nonsteroidal Inhibitors of Human Steroid 5-Reductase 1
Antonio Guarna,
Fabrizio Machetti,
Ernesto G. Occhiato, and
Dina Scarpi
, Alessandra Comerci,
Giovanna Danza,
Rosa Mancina, and
Mario Serio
, Kimber Hardy[Full Article -
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3736-3745
Nonpeptide v 3 Antagonists. 1. Transformation of a Potent, Integrin-Selective IIb3 Antagonist into a Potent v3 Antagonist
Mark E. Duggan,
Le T. Duong,
John E. Fisher,
Terence G. Hamill,
William F. Hoffman,
Joel R. Huff,
Nathan C. Ihle,
Chih-Tai Leu,
Rose M. Nagy,
James J. Perkins,
Sevgi B. Rodan,
Gregg Wesolowski,
David B. Whitman,
Amy E. Zartman,
Gideon A. Rodan, and
George D. Hartman[Full Article -
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3746-3751
Synthesis and Opioid Receptor Affinity of a Series of 2,4-Diaryl-Substituted 3,7-Diazabicylononanones
Tom Siener,
Antonella Cambareri,
Ulrich Kuhl,
Werner Englberger,
Michael Haurand,
Babette Kögel, and
Ulrike Holzgrabe[Full Article -
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3752-3760
Synthesis of Novel 3,7-Substituted-2-(3',4'-dihydroxyphenyl)flavones with Improved Antioxidant Activity
Frédérique A. A. van Acker,
Jos A. Hageman,
Guido R. M. M. Haenen,
Wim J. F. van der Vijgh,
Aalt Bast, and
Wiro M. P. B. Menge[Full Article -
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3761-3769
New Arylpiperazine Derivatives as Antagonists of the Human Cloned 5-HT4 Receptor Isoforms
Sophie Curtet,
Jean-Louis Soulier,
Ivan Zahradnik,
Mireille Giner,
Isabelle Berque-Bestel,
Jeanne Mialet,
Frank Lezoualc'h,
Patrick Donzeau-Gouge,
Sames Sicsic,
Rodolphe Fischmeister, and
Michel Langlois[Full Article -
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3770-3777
-Turned Dipeptoids as Potent and Selective CCK1 Receptor Antagonists
Mercedes Martín-Martínez,
Natalia De la Figuera,
Miriam Latorre,
Rosario Herranz,
M. Teresa García-López,
Edurne Cenarruzabeitia,
Joaquín Del Río, and
Rosario González-Muñiz[Full Article -
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3778-3785
Novel Cannabinol Probes for CB1 and CB2 Cannabinoid Receptors
Anu Mahadevan,
Craig Siegel,
Billy R. Martin,
Mary E. Abood,
Irina Beletskaya, and
Raj K. Razdan[Full Article -
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3786-3791
Binding of a Diverse Set of Ligands to Avidin and Streptavidin: An Accurate Quantitative Prediction of Their Relative Affinities by a Combination of Molecular Mechanics and Continuum Solvent Models
Bernd Kuhn and
Peter A. Kollman[Full Article -
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BRIEF ARTICLES
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3792-3798
Synthesis of New 2,6-Prolylxylidide Analogues of Tocainide as Stereoselective Blockers of Voltage-Gated Na+ Channels with Increased Potency and Improved Use-Dependent Activity
Carlo Franchini,
Filomena Corbo,
Giovanni Lentini,
Gemma Bruno,
Antonio Scilimati,
Vincenzo Tortorella,
Diana Conte Camerino, and
Annamaria De Luca[Full Article -
PDF]
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3799-3802
6-Aminoquinolones as New Potential Anti-HIV Agents
Violetta Cecchetti,
Cristina Parolin,
Stefano Moro,
Teresa Pecere,
Enrica Filipponi,
Arianna Calistri,
Oriana Tabarrini,
Barbara Gatto,
Manlio Palumbo,
Arnaldo Fravolini, and
Giorgio Palu'\t[Full Article -
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3803-3808
Melanoma Peptide MART-1(27-35) Analogues with Enhanced Binding Capacity to the Human Class I Histocompatibility Molecule HLA-A2 by Introduction of a -Amino Acid Residue: Implications for Recognition by Tumor-Infiltrating Lymphocytes
Gilles Guichard,
Annette Zerbib,
Frédérique-Anne Le Gal,
Johan Hoebeke,
Francine Connan,
Jeannine Choppin,
Jean-Paul Briand, and
Jean-Gérard Guillet[Full Article -
PDF]
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3809-3812
Synthesis, Antibacterial, and Cytotoxic Evaluation of Certain 7-Substituted Norfloxacin Derivatives
Kuo-Chang Fang,
Yeh-Long Chen,
Jia-Yuh Sheu,
Tai-Chi Wang, and
Cherng-Chyi Tzeng[Full Article -
PDF]
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BOOK REVIEWS
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3813-3813
| Platinum-Based Drugs in Cancer Therapy Edited by Lloyd R. Kendall and Nicholas P. Farrell. Humana Press, Totowa, NJ. 2000. xii + 341 pp. 16 × 23.5 cm. ISBN 0-896-03599-9. $145.00.
J. A. Cowan
[Full Article -
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3813-3813
| Traditional Chinese Medicine - Molecular Structures, Natural Sources, and Applications By X. Yan, J. Zhou, and G. Xie. Edited and with an introduction by G. W. A. Milne. Ashgate Publishing, Ltd., Hampshire, U.K. 1999. vii + 1024 pp. 17.5 ± 25 cm. ISBN 0 566 08210 1. $295.00.
Kuo-Hsiung Lee
[Full Article -
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3814-3814
| [Full Article -
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